The Role of VDR Gene Polymorphisms in Vitamin D Supplementation

Virtual data rooms (VDRs) are secure storage facilities for documents that are used in business transactions, legal proceedings or IPOs. The VDR is accessible via a specific Internet connection that allows only authorized persons to access and edit the data. Virtual data rooms are often utilized by companies involved in M&A deals, as they provide the security and safety for the parties to exchange sensitive documents that might be leaked or compromised by email, fax or even regular mail.

The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling is involved in various biological processes that include metabolic processes involving calcium and phosphorous, parathormone release, cell proliferation and control of adaptive and innate immunity.

A T > C base alteration in the promoter region of the VDR variant rs11568820 eliminates the binding site for transcription factor Cdx2 that is upstream of exon 1e and leads to the production of a lower amount of protein and reduced transcriptional activity. The F allele of this variant can be found in high numbers in Asians and Europeans and at a lower frequency in Sub-Saharan Africa.

The results of this research improve our understanding of how VDR gene polymorphisms modulate the response to dietary supplements with calcitriol. The carriers of the TaqI polymorphism and FF genotype of the FokI polymorphism show higher transcriptional activation of VDR and are associated with increased calcium absorption and bone mineral density as well as an increase in the risk of fractures [34, 35[34, 35]. Further research using more homogeneous designs is required to enhance our understanding of how these genetic variations affect vitamin D supplementation and its clinical importance.

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